Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | TLR4 | O00206 | 2/20 | 0.36 |
| ▸ | TLR2 | O60603 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550492 | 1.00 | KDR (0.43) | KDRCHEK1FGFR1PPARGLCK | |
| SCHEMBL5249048 | 0.90 | CHEK1 (0.49) | KDRCHEK1FGFR1PPARGLCK | |
| SCHEMBL5249958 | 0.90 | CHEK1 (0.49) | KDRCHEK1FGFR1PPARGLCK | |
| SCHEMBL6710656 | 0.83 | SRC (0.35) | PPARGABL1RELASRC | |
| SCHEMBL6710657 | 0.83 | SRC (0.35) | PPARGABL1RELASRC | |
| SCHEMBL5247487 | 0.80 | ALK (0.52) | KDRLMNAMAPTRELA | |
| SCHEMBL5256522 | 0.79 | KHK (0.39) | CHEK1FGFR1ABL1RELASRC | |
| SCHEMBL5252070 | 0.78 | CASP3 (0.46) | RELA | |
| SCHEMBL28938204 | 0.78 | RECQL (0.42) | LMNAMAPTABL1RELASRC | |
| SCHEMBL7553518 | 0.76 | KDR (0.41) | KDRFGFR1CDK4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218348-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001002369-A2 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |