Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630763 | 1.00 | KDM4E (0.62) | KDM4EMAPTGAANPC1MAPK1 | |
| SCHEMBL28404299 | 0.86 | MAPT (0.55) | KDM4EMAPTGAANPC1MAPK1 | |
| SCHEMBL15628211 | 0.85 | MAPT (0.49) | MAPTGAANPC1MAPK1HTT | |
| SCHEMBL10396987 | 0.83 | MAPT (0.47) | MAPTGAAHTTPOLBMAPK14 | |
| SCHEMBL14916404 | 0.83 | MAPT (0.61) | KDM4EMAPTGAANPC1MAPK1 | |
| SCHEMBL27585830 | 0.83 | MAPT (0.50) | KDM4EMAPTGAAPOLBAKR1C3 | |
| SCHEMBL29356028 | 0.80 | NPSR1 (0.60) | MAPTGAANPC1MAPK1HTT | |
| SCHEMBL305558 | 0.80 | NPSR1 (0.60) | MAPTGAANPC1MAPK1HTT | |
| SCHEMBL9748170 | 0.80 | ABCB11 (0.51) | MAPTGAAPTGS2LMNA | |
| SCHEMBL15793401 | 0.79 | MAPT (0.50) | KDM4EMAPTGAAPOLBAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980369-A1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049162-A1 | SULFONAMIDES FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |