Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549957 | 0.95 | KDR (0.49) | KDRFLT1FLT4HRH3KDM4E | |
| SCHEMBL7549584 | 0.93 | KDR (0.52) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7548335 | 0.92 | KDR (0.51) | KDRFLT1FLT4HRH3KDM4E | |
| SCHEMBL7554600 | 0.88 | KDR (0.54) | KDRFLT1FLT4HRH3AVPR1B | |
| SCHEMBL7549411 | 0.88 | KDR (0.58) | KDRFLT1FLT4HRH3GSK3B | |
| SCHEMBL7553606 | 0.87 | KDR (0.49) | KDRFLT1FLT4ALDH1A1GSK3B | |
| SCHEMBL7549925 | 0.86 | KDR (0.67) | KDRFLT1FLT4HRH3GSK3B | |
| SCHEMBL7549070 | 0.86 | KDR (0.49) | KDRFLT1FLT4KMT2A | |
| SCHEMBL7549814 | 0.86 | FLT1 (0.47) | KDRFLT1FLT4HRH3KDM4E | |
| SCHEMBL7555272 | 0.85 | KDR (0.55) | KDRFLT1FLT4HRH3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |