SCHEMBL7553606

SCHEMBL7553606

COc1cccc(-c2cncc(-c3cn(CCN4CCOCC4)c4cccc(Cl)c34)c2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 4/20 0.49
FLT1 P17948 1/20 0.49
FLT4 P35916 1/20 0.49
CYP1A2 P05177 3/20 0.47
CYP3A4 P08684 3/20 0.47
CYP2D6 P10635 3/20 0.47
HSD17B10 Q99714 2/20 0.47
LMNA P02545 1/20 0.47
TP53 P04637 1/20 0.47
ALOX15 P16050 1/20 0.47
HIF1A Q16665 1/20 0.47
ALDH1A1 P00352 3/20 0.43
TSHR P16473 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
SLC2A1 P11166 2/20 0.43
USP2 O75604 2/20 0.43
CLK4 Q9HAZ1 2/20 0.43
MKNK2 Q9HBH9 1/20 0.41
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7549957 0.92 KDR (0.49) KDRFLT1FLT4CYP1A2CYP3A4
SCHEMBL7994332 0.92 KDR (0.50) KDRFLT1FLT4CYP1A2CYP3A4
SCHEMBL7986598 0.88 KDR (0.53) KDRFLT1FLT4LMNATP53
SCHEMBL7986909 0.88 KDR (0.57) KDRFLT1FLT4CYP1A2CYP3A4
SCHEMBL7549584 0.87 KDR (0.52) KDRFLT1FLT4GSK3B
SCHEMBL7551265 0.87 KDR (0.50) KDRFLT1FLT4ALDH1A1GSK3B
SCHEMBL7555654 0.87 AVPR1B (0.38) KDRFLT1FLT4CYP1A2CYP3A4
SCHEMBL7990934 0.86 KDR (0.66) KDRFLT1FLT4CYP1A2CYP3A4
SCHEMBL7990656 0.85 CYP1A2 (0.48) KDRFLT1FLT4CYP1A2CYP3A4
SCHEMBL7990426 0.85 KDR (0.54) KDRFLT1FLT4SLC2A1GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1147107-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2002-05-22 EP claimed
EP-1147107-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-10-24 EP claimed
WO-2000043393-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-07-27 WO claimed
EP-1147107-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2002-05-22 EP disclosed
EP-1147107-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-10-24 EP disclosed
US-6265403-B1 TYROSINE INHIBITORS MERCK & CO., INC. 2001-07-24 US disclosed
WO-2000043393-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-07-27 WO disclosed