Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 14/20 | 0.58 |
| ▸ | EGFR | P00533 | 13/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760093 | 0.82 | EGFR (0.52) | ERBB2EGFRERBB4AURKB | |
| SCHEMBL7550716 | 0.81 | EGFR (0.58) | ERBB2EGFR | |
| SCHEMBL4763230 | 0.81 | EGFR (0.62) | ERBB2EGFRERBB4AURKB | |
| SCHEMBL7550038 | 0.80 | ERBB2 (0.58) | ERBB2EGFRERBB4 | |
| SCHEMBL2999764 | 0.77 | ERBB2 (0.68) | ERBB2EGFRERBB4CHEK2ROS1 | |
| SCHEMBL6767035 | 0.77 | EGFR (0.64) | ERBB2EGFRERBB4CHEK2ROS1 | |
| SCHEMBL6766836 | 0.77 | EGFR (0.72) | ERBB2EGFRERBB4CHEK2ROS1 | |
| Hydrochloric Acid SCHEMBL3319025 | 0.77 | ERBB2 (0.67) | ERBB2EGFRERBB4CHEK2ROS1 | |
| SCHEMBL3320423 | 0.77 | ERBB2 (0.61) | ERBB2EGFRERBB4CHEK2ROS1 | |
| SCHEMBL7097199 | 0.76 | ERBB2 (0.62) | ERBB2EGFRERBB4CHEK2ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912559-B1 | FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2002-11-06 | — | — | EP | claimed |