Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.57 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7518817 | 1.00 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL10421502 | 0.96 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL7516725 | 0.96 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL7514413 | 0.95 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2 | |
| SCHEMBL7510877 | 0.91 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL7516606 | 0.90 | CYSLTR1 (0.48) | CYSLTR1CYSLTR2 | |
| SCHEMBL7717000 | 0.89 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2 | |
| SCHEMBL7715810 | 0.89 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2 | |
| SCHEMBL10534084 | 0.89 | CYSLTR2 (0.47) | CYSLTR1CYSLTR2 | |
| SCHEMBL7007631 | 0.88 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030665-A4 | THERAPEUTIC USES OF QUINOLINE DERIVATIVES | AVENTIS PHARM PROD INC (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1030665-A1 | THERAPEUTIC USES OF QUINOLINE DERIVATIVES | Aventis Pharmaceuticals Products Inc. (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999020275-A1 | THERAPEUTIC USES OF QUINOLINE DERIVATIVES | AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) | 1999-04-29 | — | — | WO | disclosed |
| US-5059610-A | QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |