SCHEMBL7552045

SCHEMBL7552045

CCn1nc(Cc2ccc(O)cc2)cc1C1CCN(CC2CC(N(C)[C@@H](C(=O)O)C(C)C)CC2c2cccc(F)c2)CC1

nearest known ligand 0.91

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 20/20 0.91
KCNH2 Q12809 4/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5761229 0.99 CCR5 (0.90) CCR5KCNH2
Hydrochloric Acid SCHEMBL5764794 0.95 CCR5 (0.92) CCR5KCNH2
SCHEMBL7216659 0.95 CCR5 (1.00) CCR5KCNH2
Hydrochloric Acid SCHEMBL5764951 0.95 CCR5 (0.91) CCR5KCNH2
Hydrochloric Acid SCHEMBL5764570 0.94 CCR5 (0.99) CCR5KCNH2
Hydrochloric Acid SCHEMBL5761955 0.94 CCR5 (0.99) CCR5KCNH2
SCHEMBL7550592 0.94 CCR5 (0.92) CCR5KCNH2
SCHEMBL7552097 0.94 CCR5 (0.90) CCR5KCNH2
Hydrochloric Acid SCHEMBL5765362 0.94 CCR5 (0.90) CCR5KCNH2
Hydrochloric Acid SCHEMBL5762313 0.93 CCR5 (0.89) CCR5KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1192133-A1 N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-04-03 EP disclosed
WO-2000076972-A1 N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-12-21 WO disclosed