Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.56 |
| ▸ | RAB9A | P51151 | 12/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020638 | 0.93 | MKNK2 (0.52) | NPC1RAB9AMKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL7549868 | 0.84 | NPC1 (0.44) | NPC1RAB9AMKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL7019700 | 0.82 | NPC1 (0.42) | NPC1RAB9AMKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL7027073 | 0.82 | FGFR1 (0.54) | MKNK1MKNK2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL7553642 | 0.81 | SMN1; SMN2 (0.46) | NPC1RAB9AMKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL7014887 | 0.80 | LCK (0.69) | NPC1RAB9AMKNK1MKNK2LCK | |
| SCHEMBL7020932 | 0.76 | MKNK2 (0.51) | NPC1RAB9AMKNK1MKNK2SMN1; SMN2 | |
| SCHEMBL7024738 | 0.76 | ROCK1 (0.62) | MKNK1MKNK2LCK | |
| SCHEMBL7022787 | 0.76 | LCK (0.70) | NPC1RAB9AMKNK1MKNK2LCK | |
| SCHEMBL7022474 | 0.75 | LCK (0.73) | NPC1RAB9AMKNK1MKNK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206260-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1206260-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| US-6329380-B1 | PYRIMIDINE BENZIMIDIZAZOLE, PYRIMIDINEIMIDAZOLE OR PYRIDINE IMIDAZOLE COMPOUNDS FOR ANTICANCER AGENTS OR ATHEROSCLEROSIS | MERCK & CO., INC. | 2001-12-11 | — | — | US | disclosed |
| WO-2001000207-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |