Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549868 | 0.82 | NPC1 (0.44) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL7552289 | 0.81 | NPC1 (0.56) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL7019700 | 0.80 | NPC1 (0.42) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL7022258 | 0.79 | LCK (0.63) | SMN1; SMN2NPC1RAB9ALMNALCK | |
| SCHEMBL7027073 | 0.75 | FGFR1 (0.54) | LMNAHPGDLCKMKNK2ALDH1A1 | |
| SCHEMBL7020638 | 0.74 | MKNK2 (0.52) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7576394 | 0.74 | LCK (0.48) | SMN1; SMN2NPC1RAB9ALMNALCK | |
| SCHEMBL7494174 | 0.72 | ROCK1 (0.44) | SMN1; SMN2LMNALCKMKNK2ROCK1 | |
| SCHEMBL7018051 | 0.72 | LCK (0.55) | SMN1; SMN2LMNALCKROCK1ALDH1A1 | |
| SCHEMBL7020443 | 0.71 | FGFR1 (0.43) | LCKMKNK2ROCK1MAP3K14MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206260-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1206260-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| US-6329380-B1 | PYRIMIDINE BENZIMIDIZAZOLE, PYRIMIDINEIMIDAZOLE OR PYRIDINE IMIDAZOLE COMPOUNDS FOR ANTICANCER AGENTS OR ATHEROSCLEROSIS | MERCK & CO., INC. | 2001-12-11 | — | — | US | disclosed |
| WO-2001000207-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |