Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 6/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL758490 | 0.85 | NR3C2 (0.58) | NR3C2SCN9ABRD4CYP17A1 | |
| SCHEMBL755880 | 0.82 | NR3C2 (0.48) | NR3C2SCN9ABRD4HAVCR2 | |
| SCHEMBL753816 | 0.82 | NR3C2 (0.49) | NR3C2SCN9ABRD4 | |
| SCHEMBL754323 | 0.80 | NR3C2 (0.49) | NR3C2SCN9ABRD4 | |
| SCHEMBL755980 | 0.80 | NR3C2 (0.56) | NR3C2BRD4MEN1LMNAKMT2A | |
| SCHEMBL754215 | 0.79 | NR3C2 (0.61) | NR3C2BRD4 | |
| SCHEMBL754108 | 0.79 | NR3C2 (0.51) | NR3C2SCN9ABRD4 | |
| SCHEMBL755343 | 0.79 | NR3C2 (0.46) | NR3C2SCN9ABRD4 | |
| SCHEMBL753801 | 0.79 | NR3C2 (0.52) | NR3C2SCN9ABRD4HAVCR2 | |
| SCHEMBL2344884 | 0.78 | NR3C2 (0.52) | NR3C2SCN9ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | claimed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | claimed |