Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 6/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL755233 | 0.85 | NR3C2 (0.47) | NR3C2CYP17A1SCN9ABRD4 | |
| SCHEMBL756101 | 0.83 | NR3C2 (0.61) | NR3C2MAPK1GAAHPGDCYP17A1 | |
| SCHEMBL755327 | 0.83 | NR3C2 (0.61) | NR3C2MAPK1GAAHPGDCYP17A1 | |
| SCHEMBL753742 | 0.82 | NR3C2 (0.61) | NR3C2MAPK1GAAHPGDBRD4 | |
| SCHEMBL756434 | 0.81 | NR3C2 (0.64) | NR3C2SCN9ABRD4ADRA1DADRA1A | |
| SCHEMBL754298 | 0.80 | NR3C2 (0.63) | NR3C2MAPK1GAAHPGDBRD4 | |
| SCHEMBL756423 | 0.80 | NR3C2 (0.63) | NR3C2MAPK1GAAHPGDBRD4 | |
| SCHEMBL755328 | 0.79 | NR3C2 (0.65) | NR3C2MAPK1GAAHPGDSCN9A | |
| SCHEMBL756319 | 0.79 | NR3C2 (0.56) | NR3C2GAAHPGDSCN9A | |
| SCHEMBL753962 | 0.79 | NR3C2 (0.59) | NR3C2MAPK1GAAHPGDCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | claimed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | claimed |