SCHEMBL7552508

SCHEMBL7552508

COC(=O)c1ccc(Cl)c(Cl)c1N(C)C(=O)OC(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.39
HTT P42858 3/20 0.39
NPSR1 Q6W5P4 2/20 0.39
ABL1 P00519 1/20 0.36
PTGS2 P35354 1/20 0.35
ALDH1A1 P00352 1/20 0.35
TSHR P16473 1/20 0.35
MAPT P10636 3/20 0.35
TUBB4A P04350 1/20 0.34
TUBB P07437 1/20 0.34
TUBA3C P0DPH7 1/20 0.34
TUBA1B P68363 1/20 0.34
TUBA4A P68366 1/20 0.34
TUBB4B P68371 1/20 0.34
TUBB3 Q13509 1/20 0.34
TUBB2A Q13885 1/20 0.34
TUBB8 Q3ZCM7 1/20 0.34
TUBA3E Q6PEY2 1/20 0.34
TUBA1A Q71U36 1/20 0.34
TUBA1C Q9BQE3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7555016 0.87 ABL1 (0.41) LMNAHTTNPSR1ABL1PTGS2
SCHEMBL7553110 0.86 LMNA (0.41) LMNAHTTNPSR1ALDH1A1TSHR
SCHEMBL7550786 0.81 KMT2A (0.41) LMNANPSR1ABL1PTGS2ALDH1A1
SCHEMBL7550961 0.78 LMNA (0.36) LMNAHTTNPSR1ALDH1A1KMT2A
SCHEMBL7558739 0.77 CA12 (0.38) LMNAHTTNPSR1ALDH1A1TSHR
SCHEMBL7643698 0.76 ABL1 (0.49) LMNAHTTNPSR1ABL1ALDH1A1
SCHEMBL7558764 0.76 TSHR (0.40) PTGS2ALDH1A1TSHRMAPTMEN1
SCHEMBL7554619 0.73 KMT2A (0.52) LMNAHTTNPSR1ABL1PTGS2
SCHEMBL7557166 0.72 CYP4F2 (0.40) LMNAHTTALDH1A1TSHRMAPT
SCHEMBL7550436 0.71 SYK (0.35) LMNAHTTNPSR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0734380-B1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES AVENTIS AGRICULTURE LTD (GB) 2002-07-10 EP disclosed
US-6114538-A 2-POSITION OF BENZOY RING OF 4-BENZOYLISOXAZOLE DERIVATIVE IS SUBSTITUTED AND PARTICULARLY USED AGAINST MONOCOTYLEDONOUS WEEDS BY POST-EMEREGENECE APPLICATION RHONE POULENC AGRICULTURE LIMITED (GB) 2000-09-05 US disclosed
US-5998653-A CHEMICAL INTERMEDIATE FOR HERBICIDES RHONE POULENC AGRICULTURE LIMITED (GB) 1999-12-07 US disclosed