Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.66 |
| ▸ | AKT2 | P31751 | 15/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.61 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.50 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7552840 | 1.00 | CHEK1 (0.66) | CHEK1AKT2PDPK1PDK1CHEK2 | |
| SCHEMBL7551826 | 0.91 | CHEK1 (0.64) | CHEK1AKT2PDPK1PDK1CHEK2 | |
| SCHEMBL7551817 | 0.91 | CHEK1 (0.64) | CHEK1AKT2PDPK1PDK1CHEK2 | |
| SCHEMBL7600606 | 0.85 | CHEK1 (0.59) | CHEK1AKT2PDPK1PDK1CHEK2 | |
| SCHEMBL7600600 | 0.85 | CHEK1 (0.59) | CHEK1AKT2PDPK1PDK1CHEK2 | |
| SCHEMBL8585108 | 0.85 | PAK1 (0.66) | AKT2PDPK1PDK1PAK1 | |
| SCHEMBL8585109 | 0.85 | PAK1 (0.66) | AKT2PDPK1PDK1PAK1 | |
| SCHEMBL8467707 | 0.83 | CHEK1 (0.73) | CHEK1PDPK1CHEK2CDK1SRC | |
| SCHEMBL8467705 | 0.83 | CHEK1 (0.73) | CHEK1PDPK1CHEK2CDK1SRC | |
| SCHEMBL7550675 | 0.83 | CHEK1 (0.67) | CHEK1AKT2PDPK1PDK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715628-B1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA SPA (IT) | 2002-10-02 | — | — | EP | claimed |