Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 16/20 | 0.62 |
| ▸ | MMP1 | P03956 | 14/20 | 0.62 |
| ▸ | MMP9 | P14780 | 15/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318605 | 0.96 | MMP13 (0.60) | MMP13MMP1MMP9ADAM17KEAP1 | |
| SCHEMBL7819516 | 0.91 | MMP13 (0.61) | MMP13MMP1MMP9ADAM17KEAP1 | |
| SCHEMBL7316835 | 0.86 | MMP13 (0.71) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7322655 | 0.85 | MMP13 (0.83) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7317725 | 0.85 | MMP13 (0.62) | MMP13MMP1MMP9ADAM17KEAP1 | |
| SCHEMBL7323146 | 0.83 | MMP13 (0.73) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7504634 | 0.83 | MMP13 (0.60) | MMP13MMP1MMP9ADAM17KEAP1 | |
| SCHEMBL7316120 | 0.82 | MMP13 (0.72) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7315647 | 0.82 | MMP13 (0.68) | MMP13MMP1MMP9ADAM17 | |
| SCHEMBL7325570 | 0.81 | MMP13 (0.72) | MMP13MMP1MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |