Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6261047 | 1.00 | CHEK1 (0.69) | CHEK1PDPK1CHEK2CDK1SRC | |
| SCHEMBL8467707 | 0.84 | CHEK1 (0.73) | CHEK1PDPK1CHEK2CDK1SRC | |
| SCHEMBL8467705 | 0.84 | CHEK1 (0.73) | CHEK1PDPK1CHEK2CDK1SRC | |
| SCHEMBL5475533 | 0.83 | NTRK1 (0.68) | CHEK1PDPK1CDK1NTRK1RET | |
| SCHEMBL14448943 | 0.83 | NTRK1 (0.68) | CHEK1PDPK1CDK1NTRK1RET | |
| SCHEMBL5475520 | 0.83 | NTRK1 (0.68) | CHEK1PDPK1CDK1NTRK1RET | |
| SCHEMBL8464117 | 0.82 | CHEK1 (1.00) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL857064 | 0.82 | CHEK1 (1.00) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL8464120 | 0.82 | CHEK1 (1.00) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7553386 | 0.81 | CHEK1 (0.69) | CHEK1PDPK1CHEK2CDK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715628-B1 | SUBSTITUTED AZAINDOLYLIDENE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA SPA (IT) | 2002-10-02 | — | — | EP | claimed |