Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | NOS2 | P35228 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL27803449 | 0.97 | MEN1 (0.58) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Biguanide SCHEMBL22127095 | 0.85 | MEN1 (0.50) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL8009459 | 0.84 | — | — | |
| Morpholine SCHEMBL6366032 | 0.83 | MEN1 (0.48) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Biguanide SCHEMBL22127045 | 0.83 | MEN1 (0.48) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Trichloroacetic Acid SCHEMBL10611439 | 0.82 | MEN1 (0.42) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL7987130 | 0.82 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL2520893 | 0.82 | KDM4E (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Biguanide SCHEMBL22127044 | 0.81 | MEN1 (0.46) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL8004690 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115955965-A | Products of manufacture and methods for treating, ameliorating or preventing microbial infections | 拓比利亚欧斯特有限公司 | 2023-04-11 | — | — | CN | claimed |
| CN-115666587-A | N4-hydroxycytidine and derivatives and related antiviral uses thereof | 埃默里大学 | 2023-01-31 | — | — | CN | claimed |
| CN-113666660-B | Concrete antifreezing agent and application thereof | 江西省圣源商品混凝土有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-113666660-A | Concrete antifreezing agent and application thereof | 江西省圣源商品混凝土有限公司 | 2021-11-19 | — | — | CN | claimed |
| CN-110828194-B | Method for preparing layered beta-nickel hydroxide/graphene material by utilizing induction effect of surface charge | 蚌埠学院 | 2021-05-28 | — | — | CN | claimed |
| CN-111470603-A | Composite denitrification agent for wastewater treatment | 绍兴国鑫环保工程有限公司 | 2020-07-31 | — | — | CN | claimed |
| CN-107955974-B | Texturing additive for inverted pyramid textured monocrystalline silicon wafer and application thereof | 常州时创能源股份有限公司 | 2020-06-09 | — | — | CN | claimed |
| CN-110828194-A | Method for preparing layered β -nickel hydroxide/graphene material by utilizing induction effect of surface charge | 蚌埠学院 | 2020-02-21 | — | — | CN | claimed |
| CN-110381960-A | The bicarbonate of reinforcing agent as antimicrobial | 麦克马斯特大学 | 2019-10-25 | — | — | CN | claimed |
| CN-106978746-B | A kind of ink-jet cloth printing technique | 泉州市众科专利技术标准化研究院有限责任公司 | 2019-05-17 | — | — | CN | claimed |
| CN-108008565-A | A kind of preparation method of the quantum dot color filter based on self assembly | 福州大学 | 2018-05-08 | — | — | CN | claimed |
| CN-107955974-A | The flocking additive of inverted pyramid textured mono-crystalline silicon piece and its application | 常州时创能源科技有限公司 | 2018-04-24 | — | — | CN | claimed |
| CN-107706375-A | The method for preparing manganese base sodium ion composite oxide positive pole material | 济宁市无界科技有限公司 | 2018-02-16 | — | — | CN | claimed |
| CN-107173399-A | It is a kind of that there is the biocide preparation for killing various pathogens | 广德美处电子商务有限公司 | 2017-09-19 | — | — | CN | claimed |
| CN-107141698-A | A kind of graphene is combined multi-functional resins of ABS and preparation method thereof | 南通强生光电科技有限公司 | 2017-09-08 | — | — | CN | claimed |
| CN-105885474-B | A kind of preparation method of carbon black Electrostatic Absorption carbon nanotube conducting filler | 国网浙江省电力公司湖州供电公司 | 2017-09-08 | — | — | CN | claimed |
| CN-107057192-A | Functionalization graphene strengthens the preparation method of composite polyolefine material | 南通强生光电科技有限公司 | 2017-08-18 | — | — | CN | claimed |
| CN-106978746-A | A kind of ink-jet cloth printing technique | 泉州市众科专利技术标准化研究院有限责任公司 | 2017-07-25 | — | — | CN | claimed |
| CN-105885474-A | Preparation method of carbon black-electrostatically adsorbed carbon nano tube conductive filler | 国网浙江省电力公司湖州供电公司 | 2016-08-24 | — | — | CN | claimed |
| CN-101837177-A | Method for high-selectivity oxidation and oxygen-adding open loop of catechol substance | YANTAI INST OF COASTAL ZONE RES | 2010-09-22 | — | — | CN | claimed |