Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 9/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ESRRB | O95718 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29102200 | 0.82 | KDM4E (0.46) | ESRRGHRH3ESR1KDM4EALDH1A1 | |
| SCHEMBL9099717 | 0.79 | LTA4H (0.57) | LTA4HESR1ESRRBSMN1; SMN2 | |
| SCHEMBL29102210 | 0.79 | KDM4E (0.42) | ESRRGHRH3LTA4HKEAP1NFE2L2 | |
| SCHEMBL11430974 | 0.79 | TDP1 (0.50) | HRH3LTA4HKEAP1NFE2L2KDM4E | |
| SCHEMBL30567457 | 0.78 | SLC2A1 (0.50) | LTA4HALDH1A1SMN1; SMN2 | |
| SCHEMBL6317820 | 0.76 | AOC3 (0.49) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2554940 | 0.76 | HRH3 (0.72) | ESRRGHRH3LTA4HKEAP1NFE2L2 | |
| SCHEMBL11382574 | 0.76 | KDM4E (0.44) | HRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6138444 | 0.76 | HDAC1 (0.54) | ESR1 | |
| SCHEMBL6138449 | 0.76 | HDAC1 (0.54) | ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235776-A1 | TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Hormos Medical Corporation (FI) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001036360-A1 | TRIPHENYLALKENE DERIVATIVES AND THEIR USE AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | HORMOS MEDICAL CORPORATION (FI) | 2001-05-25 | — | — | WO | disclosed |