Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928868 | 0.77 | CHRNB4 (0.50) | CHRNB4CHRNA3CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6928871 | 0.77 | CHRNB4 (0.50) | CHRNB4CHRNA3CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL7634555 | 0.69 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4101485 | 0.69 | CARM1 (0.45) | CHRNB4CHRNA3CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL23848517 | 0.68 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2GAARAB9A | |
| Fluoride SCHEMBL4578822 | 0.68 | CARM1 (0.33) | CARM1PRMT6ALDH1A1MAPTMEN1 | |
| SCHEMBL13162978 | 0.67 | KAT2B (0.56) | CHRNB4CHRNA3CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL7106481 | 0.67 | KAT2B (0.56) | CHRNB4CHRNA3CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL4443892 | 0.67 | KAT2B (0.56) | CHRNB4CHRNA3CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6287003 | 0.67 | SSTR4 (0.41) | CARM1PRMT6CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1061919-A4 | NOVEL OPIATE COMPOUNDS, METHODS OF MAKING AND METHODS OF USE | RES TRIANGLE INST (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1061919-A1 | NOVEL OPIATE COMPOUNDS, METHODS OF MAKING AND METHODS OF USE | Carrol, Frank Ivy (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999045925-A1 | NOVEL OPIATE COMPOUNDS, METHODS OF MAKING AND METHODS OF USE | RESEARCH TRIANGLE INSTITUTE (US) | 1999-09-16 | — | — | WO | disclosed |