Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28107947 | 0.83 | EPHX1 (0.75) | EPHX1CHRM1ESR1ESR2ALDH1A1 | |
| SCHEMBL4506554 | 0.80 | EPHX1 (0.71) | EPHX1ALDH1A1MEN1KMT2A | |
| SCHEMBL6802549 | 0.79 | EPHX1 (0.58) | EPHX1CHRM1ALDH1A1HPGDKMT2A | |
| SCHEMBL1516139 | 0.79 | EPHX1 (1.00) | EPHX1CHRM1ALDH1A1PTGS1UBE2N | |
| SCHEMBL11021257 | 0.78 | EPHX1 (0.77) | EPHX1CHRM1ESR1ESR2ALDH1A1 | |
| SCHEMBL8620330 | 0.77 | EPHX1 (0.96) | EPHX1CHRM1ALDH1A1PTGS1UBE2N | |
| SCHEMBL28108056 | 0.77 | EPHX1 (0.71) | EPHX1ALDH1A1BACE1 | |
| SCHEMBL2093765 | 0.75 | TAAR1 (0.54) | ALDH1A1HPGD | |
| SCHEMBL1911097 | 0.75 | TAAR1 (0.54) | ALDH1A1HPGD | |
| SCHEMBL12282802 | 0.75 | TAAR1 (0.54) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946495-B1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6353128-B1 | FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK. | ELI LILLY AND COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-0946495-A4 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0946495-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024756-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |