⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24205842 | 0.81 | — | — | |
| SCHEMBL10046227 | 0.78 | — | — | |
| SCHEMBL12863852 | 0.78 | — | — | |
| SCHEMBL13618663 | 0.78 | — | — | |
| SCHEMBL2625545 | 0.78 | — | — | |
| SCHEMBL10460020 | 0.78 | — | — | |
| SCHEMBL4761841 | 0.78 | — | — | |
| SCHEMBL10046224 | 0.78 | — | — | |
| SCHEMBL21345128 | 0.78 | — | — | |
| SCHEMBL2625543 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479488-B1 | GOOD IN VITRO AFFINITY FOR THE STRYCHNINE INSENSITIVE GLYCINE BINDING SITE ASSOCIATED WITH THE NMDA RECEPTOR COMPLEX BUT ALSO GOOD IN VIVO ACTIVITY WHEN ADMINISTERED SYSTEMICALLY | GLAXO WELLCOME SPA (IT) | 2002-11-12 | — | — | US | disclosed |
| EP-0922034-B1 | TETRAHYDROQUINOLINE DERIVATIVES AS EAA ANTAGONISTS | GLAXO WELLCOME SPA (IT) | 2002-07-24 | — | — | EP | disclosed |
| EP-0922034-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS EAA ANTAGONISTS | GLAXO WELLCOME S.p.A. (IT) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998007704-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS EAA ANTAGONISTS | GLAXO WELLCOME S.P.A. (IT) | 1998-02-26 | — | — | WO | disclosed |