Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 2/20 | 0.35 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7581722 | 0.84 | RYR2 (0.49) | RYR2HTTALDH1A1TSHRTP53 | |
| SCHEMBL7555406 | 0.83 | RYR2 (0.48) | RYR2SMN1; SMN2ALDH1A1TSHRF12 | |
| SCHEMBL7559963 | 0.76 | RYR2 (0.63) | RYR2ALDH1A1KDM1ANOTUMMEN1 | |
| SCHEMBL7559448 | 0.74 | NOTUM (0.46) | RYR2HTTNOTUMKCNK3 | |
| SCHEMBL7556815 | 0.70 | GAA (0.40) | RYR2SMN1; SMN2ALDH1A1TSHRTP53 | |
| SCHEMBL31424250 | 0.67 | HPGD (0.36) | RYR2ALDH1A1NOTUMGAAMEN1 | |
| SCHEMBL26344323 | 0.67 | RYR2 (0.71) | RYR2TSHR | |
| SCHEMBL7557030 | 0.64 | RYR2 (0.53) | RYR2ALDH1A1GAAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8528982 | 0.63 | RYR2 (0.51) | RYR2ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL7558332 | 0.63 | RYR2 (0.53) | RYR2HTTALDH1A1NOTUMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218010-A2 | 1,4-BENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | Knoll GmbH (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001000185-A2 | 1,4-DENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | KNOLL GMBH (DE) | 2001-01-04 | — | — | WO | claimed |
| EP-0667866-B1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | KNOLL AG (DE) | 1998-03-11 | — | — | EP | claimed |
| US-5580866-A | Therapeutic 1,4-thiazepines | THE BOOTS COMPANY PLC (GB) | 1996-12-03 | — | — | US | claimed |
| EP-0667866-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | Knoll AG (DE) | 1995-08-23 | — | — | EP | claimed |
| WO-1994011360-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | THE BOOTS COMPANY PLC (GB) | 1994-05-26 | — | — | WO | claimed |
| EP-1218010-A2 | 1,4-BENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | Knoll GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001000185-A2 | 1,4-DENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | KNOLL GMBH (DE) | 2001-01-04 | — | — | WO | disclosed |
| EP-0667866-B1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | KNOLL AG (DE) | 1998-03-11 | — | — | EP | disclosed |
| US-5580866-A | Therapeutic 1,4-thiazepines | THE BOOTS COMPANY PLC (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0667866-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | Knoll AG (DE) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994011360-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | THE BOOTS COMPANY PLC (GB) | 1994-05-26 | — | — | WO | disclosed |