Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7555410 | 1.00 | RYR2 (0.43) | RYR2HTR5APOLBHSD17B3ALDH1A1 | |
| SCHEMBL7561765 | 0.83 | RYR2 (0.41) | RYR2HTR5APOLBHSD17B3ALDH1A1 | |
| SCHEMBL7561767 | 0.83 | RYR2 (0.41) | RYR2HTR5APOLBHSD17B3ALDH1A1 | |
| SCHEMBL7556100 | 0.83 | RYR2 (0.43) | RYR2HTR5APOLBHSD17B3ALDH1A1 | |
| SCHEMBL7556098 | 0.83 | RYR2 (0.43) | RYR2HTR5APOLBHSD17B3ALDH1A1 | |
| SCHEMBL8526616 | 0.73 | RYR2 (0.47) | RYR2POLBHSD17B3ALDH1A1HPGD | |
| SCHEMBL8530034 | 0.73 | ALDH1A1 (0.52) | RYR2HTR5APOLBHSD17B3ALDH1A1 | |
| SCHEMBL13864441 | 0.68 | ALDH1A1 (0.47) | RYR2POLBHSD17B3ALDH1A1MAPT | |
| SCHEMBL15761043 | 0.68 | — | — | |
| SCHEMBL1319961 | 0.63 | RYR2 (0.64) | RYR2ALDH1A1GAACYP2D6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218010-A2 | 1,4-BENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | Knoll GmbH (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001000185-A2 | 1,4-DENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | KNOLL GMBH (DE) | 2001-01-04 | — | — | WO | claimed |
| EP-0667866-B1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | KNOLL AG (DE) | 1998-03-11 | — | — | EP | claimed |
| US-5580866-A | Therapeutic 1,4-thiazepines | THE BOOTS COMPANY PLC (GB) | 1996-12-03 | — | — | US | claimed |
| EP-0667866-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | Knoll AG (DE) | 1995-08-23 | — | — | EP | claimed |
| WO-1994011360-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | THE BOOTS COMPANY PLC (GB) | 1994-05-26 | — | — | WO | claimed |
| EP-1218010-A2 | 1,4-BENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | Knoll GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001000185-A2 | 1,4-DENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | KNOLL GMBH (DE) | 2001-01-04 | — | — | WO | disclosed |
| EP-0667866-B1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | KNOLL AG (DE) | 1998-03-11 | — | — | EP | disclosed |
| US-5580866-A | Therapeutic 1,4-thiazepines | THE BOOTS COMPANY PLC (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0667866-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | Knoll AG (DE) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994011360-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | THE BOOTS COMPANY PLC (GB) | 1994-05-26 | — | — | WO | disclosed |