Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7554199 | 0.99 | GRIN1 (0.34) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7548276 | 0.92 | GPR17 (0.38) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7551416 | 0.90 | GPR17 (0.34) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7550579 | 0.89 | GRIN1 (0.36) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7549065 | 0.87 | PPARD (0.35) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL7547515 | 0.86 | PPARD (0.34) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7548916 | 0.85 | GRIN1 (0.32) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL7655186 | 0.83 | PTGDR2 (0.32) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7551094 | 0.81 | MTNR1A (0.34) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B | |
| SCHEMBL7553560 | 0.79 | GRIN2D (0.35) | GRIN1GRIN2DGRIN3BGRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |