Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 5/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8529334 | 0.98 | NPSR1 (0.46) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7554452 | 0.77 | NOTUM (0.46) | RYR2GAASMN1; SMN2NOTUMLMNA | |
| SCHEMBL7555406 | 0.77 | RYR2 (0.48) | NPSR1RYR2GAASMN1; SMN2NOTUM | |
| SCHEMBL7554446 | 0.77 | ADRA2A (0.33) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7556815 | 0.76 | GAA (0.40) | NPSR1RYR2GAASMN1; SMN2LMNA | |
| SCHEMBL7556712 | 0.75 | RYR2 (0.45) | RYR2GAASMN1; SMN2NOTUMMAPT | |
| SCHEMBL17080822 | 0.72 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8248175 | 0.72 | RYR2 (0.57) | ADRA2AADRA2BADRA2CADRA1ACYP2D6 | |
| SCHEMBL28443721 | 0.71 | STS (0.45) | RYR2 | |
| SCHEMBL7554471 | 0.71 | RYR2 (0.51) | RYR2DRD2GAASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667866-B1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | KNOLL AG (DE) | 1998-03-11 | — | — | EP | claimed |
| US-5580866-A | Therapeutic 1,4-thiazepines | THE BOOTS COMPANY PLC (GB) | 1996-12-03 | — | — | US | claimed |
| EP-0667866-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | Knoll AG (DE) | 1995-08-23 | — | — | EP | claimed |
| WO-1994011360-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | THE BOOTS COMPANY PLC (GB) | 1994-05-26 | — | — | WO | claimed |
| EP-1218010-A2 | 1,4-BENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | Knoll GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001000185-A2 | 1,4-DENZOTHIAZEPINES TO TREAT OBESITY RELATED DISORDERS | KNOLL GMBH (DE) | 2001-01-04 | — | — | WO | disclosed |
| EP-0667866-B1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | KNOLL AG (DE) | 1998-03-11 | — | — | EP | disclosed |
| US-5580866-A | Therapeutic 1,4-thiazepines | THE BOOTS COMPANY PLC (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0667866-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | Knoll AG (DE) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994011360-A1 | 1,4-BENZOTHIAZEPINES USEFUL AS NEUROLOGICAL AGENTS | THE BOOTS COMPANY PLC (GB) | 1994-05-26 | — | — | WO | disclosed |