Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | FLT1 | P17948 | 2/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 10/20 | 0.44 |
| ▸ | QPCT | Q16769 | 10/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | USP14 | P54578 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557189 | 0.94 | KDR (0.54) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7554276 | 0.94 | KDR (0.52) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7551493 | 0.94 | KDR (0.57) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7548992 | 0.93 | KDR (0.56) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7548026 | 0.91 | KDR (0.60) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7549728 | 0.90 | KDR (0.54) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7551629 | 0.90 | KDR (0.60) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7549168 | 0.89 | KDR (0.54) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7554609 | 0.89 | KDR (0.52) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7549155 | 0.89 | KDR (0.56) | KDRFLT1FLT4GSK3BQPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |