Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | FLT1 | P17948 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | QPCT | Q16769 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554276 | 0.94 | KDR (0.52) | KDRFLT1FLT4KDM4EALDH1A1 | |
| SCHEMBL7551493 | 0.94 | KDR (0.57) | KDRFLT1FLT4ESR1GSK3B | |
| SCHEMBL7550504 | 0.94 | KDR (0.59) | KDRFLT1FLT4KDM4EALDH1A1 | |
| SCHEMBL7554609 | 0.92 | KDR (0.52) | KDRFLT1FLT4KDM4EALDH1A1 | |
| SCHEMBL7547482 | 0.91 | KDR (0.55) | KDRFLT1FLT4KDM4EALDH1A1 | |
| SCHEMBL7550594 | 0.91 | KDR (0.56) | KDRFLT1FLT4KDM4EALDH1A1 | |
| SCHEMBL7555221 | 0.91 | KDR (0.68) | KDRFLT1FLT4GSK3BQPCT | |
| SCHEMBL7987153 | 0.90 | KDR (0.50) | KDRFLT1FLT4KDM4EALDH1A1 | |
| SCHEMBL7990663 | 0.89 | KDR (0.73) | KDRFLT1FLT4KDM4EALDH1A1 | |
| SCHEMBL7556233 | 0.89 | KDR (0.54) | KDRFLT1FLT4ESR1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |