Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 15/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.41 |
| ▸ | HTR3A | P46098 | 6/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.36 |
| ▸ | HTR3B | O95264 | 4/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7064136 | 1.00 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3AHSD17B1 | |
| SCHEMBL7063791 | 0.91 | HSD17B1 (0.47) | CHRNA7CHRNB2CHRNA4HTR3AHSD17B1 | |
| SCHEMBL7058215 | 0.89 | CHRNA7 (0.39) | CHRNA7CHRNB2CHRNA4HTR3AHSD17B1 | |
| SCHEMBL7062040 | 0.89 | CHRNA7 (0.39) | CHRNA7CHRNB2CHRNA4HTR3AHSD17B1 | |
| SCHEMBL7064022 | 0.89 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL7063541 | 0.89 | HSD17B1 (0.40) | CHRNA7CHRNB2CHRNA4HTR3AHSD17B1 | |
| SCHEMBL7063201 | 0.88 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL7062775 | 0.88 | HSD17B1 (0.40) | CHRNA7CHRNB2CHRNA4HTR3AHSD17B1 | |
| SCHEMBL7064150 | 0.88 | CHRNA7 (0.40) | CHRNA7CHRNB2CHRNA4HTR3AHSD17B1 | |
| SCHEMBL7062713 | 0.88 | CHRNA7 (0.40) | CHRNA7CHRNB2CHRNA4HTR3AMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002015662-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | claimed |