Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 6/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.77 |
| ▸ | PIM1 | P11309 | 5/20 | 0.69 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.69 |
| ▸ | CNR1 | P21554 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | IGF1R | P08069 | 1/20 | 0.61 |
| ▸ | MMP3 | P08254 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7558356 | 1.00 | ADAMTS5 (1.00) | ADAMTS5AKR1B1PIM1PIM2CNR1 | |
| SCHEMBL5509719 | 0.94 | ADAMTS5 (0.88) | ADAMTS5AKR1B1PIM1PIM2CNR1 | |
| SCHEMBL5509720 | 0.94 | ADAMTS5 (0.88) | ADAMTS5AKR1B1PIM1PIM2CNR1 | |
| SCHEMBL1248971 | 0.87 | AKR1B1 (1.00) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL1248969 | 0.87 | AKR1B1 (1.00) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL12891780 | 0.87 | AKR1B1 (1.00) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL12891792 | 0.82 | AKR1B1 (0.81) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL1247917 | 0.82 | AKR1B1 (0.81) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL1247918 | 0.82 | AKR1B1 (0.81) | ADAMTS5AKR1B1PIM1PIM2HPGD | |
| SCHEMBL1250348 | 0.82 | PIM1 (1.00) | ADAMTS5AKR1B1PIM1PIM2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002062337-A1 | THIAZOLIDINEDIONES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-08-15 | — | — | WO | claimed |
| WO-2002062337-A1 | THIAZOLIDINEDIONES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-08-15 | — | — | WO | disclosed |