Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 9/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862440 | 0.90 | KMT2A (0.64) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL8145505 | 0.88 | HDAC4 (0.59) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL7558383 | 0.87 | HDAC4 (0.71) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL5165280 | 0.86 | HDAC4 (0.58) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL5166744 | 0.85 | HDAC4 (0.57) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL8144306 | 0.84 | HDAC4 (0.58) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL7002185 | 0.82 | HDAC4 (0.76) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL7623491 | 0.82 | HDAC4 (0.54) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL7717984 | 0.81 | HDAC4 (0.53) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL6999935 | 0.81 | HDAC4 (0.63) | HDAC4MEN1KMT2APGRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224172-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | Active Biotech AB (SE) | 2002-07-24 | — | — | EP | claimed |
| WO-2001030758-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2001-05-03 | — | — | WO | claimed |
| US-6121287-A | Quinoline derivatives | ACTIVE BIOTECH AB (SE) | 2000-09-19 | — | — | US | claimed |
| EP-1224172-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | Active Biotech AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| US-6395750-B1 | Includes laquinimod, N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxamide and its salts; breat or prostate cancer | ACTIVE BIOTECH AB (SE) | 2002-05-28 | — | — | US | disclosed |
| WO-2001030758-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2001-05-03 | — | — | WO | disclosed |
| US-6121287-A | Quinoline derivatives | ACTIVE BIOTECH AB (SE) | 2000-09-19 | — | — | US | disclosed |