Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757907 | 1.00 | BACE1 (0.41) | BACE1BACE2 | |
| SCHEMBL764637 | 0.92 | BACE1 (0.47) | BACE1BACE2 | |
| SCHEMBL764599 | 0.90 | BACE1 (0.41) | BACE1BACE2 | |
| SCHEMBL4739104 | 0.90 | BACE1 (0.41) | BACE1BACE2 | |
| SCHEMBL4786916 | 0.89 | HSD11B1 (0.41) | BACE1BACE2 | |
| SCHEMBL10262738 | 0.89 | HSD11B1 (0.41) | BACE1BACE2 | |
| SCHEMBL4786910 | 0.89 | HSD11B1 (0.41) | BACE1BACE2 | |
| SCHEMBL757501 | 0.89 | HSD11B1 (0.41) | BACE1BACE2 | |
| SCHEMBL758530 | 0.88 | BACE1 (0.54) | BACE1 | |
| SCHEMBL758731 | 0.88 | BACE1 (0.54) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910364-B1 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2012-03-21 | — | — | EP | disclosed |