SCHEMBL7560046

SCHEMBL7560046

COC(CC1(c2ccc(Cl)c(Cl)c2)CCC(=O)N(CC2CCC(F)(F)CC2)C1)OC

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TACR2 P21452 12/20 0.60
TACR1 P25103 8/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7560035 1.00 TACR2 (0.60) TACR2TACR1
SCHEMBL7563358 0.80 TACR2 (0.63) TACR2TACR1
SCHEMBL7563350 0.80 TACR2 (0.63) TACR2TACR1
SCHEMBL7811978 0.76 TACR2 (0.62) TACR2TACR1
SCHEMBL3083322 0.75 TACR2 (1.00) TACR2TACR1
SCHEMBL3083325 0.75 TACR2 (1.00) TACR2TACR1
SCHEMBL5900849 0.71 SLC6A4 (0.38) TACR2TACR1
SCHEMBL5901195 0.70 SLC6A4 (0.37) TACR2TACR1
SCHEMBL7139722 0.69 TACR2 (0.52) TACR2TACR1
SCHEMBL7139720 0.69 TACR2 (0.52) TACR2TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888337-B1 PIPERIDONE TACHYKININ ANTAGONISTS PFIZER RES & DEV (IE) 2002-06-05 EP disclosed
US-6262075-B1 Piperidone tachykinin antagonists PFIZER INC 2001-07-17 US disclosed