Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31350946 | 0.91 | ALDH1A1 (0.57) | ALDH1A1LMNATP53NLRP3 | |
| SCHEMBL2893066 | 0.81 | — | — | |
| SCHEMBL21616875 | 0.81 | ALDH1A1 (0.96) | ALDH1A1LMNATP53KEAP1NFE2L2 | |
| SCHEMBL14946980 | 0.81 | ALDH1A1 (0.62) | ALDH1A1LMNATP53NLRP3KEAP1 | |
| SCHEMBL14946970 | 0.81 | ALDH1A1 (0.62) | ALDH1A1LMNATP53NLRP3KEAP1 | |
| SCHEMBL25332003 | 0.81 | ALDH1A1 (0.96) | ALDH1A1LMNATP53KEAP1NFE2L2 | |
| SCHEMBL938891 | 0.81 | ALDH1A1 (0.96) | ALDH1A1LMNATP53KEAP1NFE2L2 | |
| SCHEMBL21622155 | 0.81 | ALDH1A1 (0.62) | ALDH1A1LMNATP53NLRP3KEAP1 | |
| SCHEMBL21616877 | 0.81 | ALDH1A1 (0.96) | ALDH1A1LMNATP53KEAP1NFE2L2 | |
| SCHEMBL14797843 | 0.81 | ALDH1A1 (0.96) | ALDH1A1LMNATP53KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002002190-A2 | PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES BY GLUTATHIONE AND PHASE II DETOXIFICATION ENZYMES | JOHNS HOPKINS SCHOOL OF MEDICINE (US) | 2002-01-10 | — | — | WO | claimed |