Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.80 |
| ▸ | LMNA | P02545 | 7/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.80 |
| ▸ | HPGD | P15428 | 4/20 | 0.80 |
| ▸ | RAB9A | P51151 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.64 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.60 |
| ▸ | TUBB | P07437 | 2/20 | 0.60 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.60 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.60 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.60 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.60 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.60 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.60 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.60 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7560814 | 1.00 | MAPT (0.80) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7558641 | 0.93 | MAPT (0.89) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7558644 | 0.93 | MAPT (0.89) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7560231 | 0.93 | MAPT (0.77) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7561872 | 0.93 | MAPT (0.77) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7560234 | 0.93 | MAPT (0.77) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7561878 | 0.93 | MAPT (0.77) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7525950 | 0.91 | TUBB4A (0.76) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7673226 | 0.91 | TUBB4A (0.76) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7533562 | 0.90 | MAPT (0.72) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020091148-A1 | 3-substituted indole antiproliferative angiogenesis inhibitors | ABBOTT LABORATORIES | 2002-07-11 | — | — | US | claimed |
| WO-2002022576-A2 | 3-SUBSTITUTED INDOLE CARBOHYDRAZIDES USEFUL AS CELL PROLIFERATION AND ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2002-03-21 | — | — | WO | claimed |
| US-6323228-B1 | INHIBITING ANGIOGENESIS IN A MAMMAL IN RECOGNIZED NEED OF SUCH TREATMENT COMPRISING ADMINISTERING TO THE MAMMAL WITH INDOLE SUBSTITUTED WITH HYDRAZIDES | ABBOTT LABORATORIES | 2001-11-27 | — | — | US | claimed |
| US-20020091148-A1 | 3-substituted indole antiproliferative angiogenesis inhibitors | ABBOTT LABORATORIES | 2002-07-11 | — | — | US | disclosed |
| WO-2002022576-A2 | 3-SUBSTITUTED INDOLE CARBOHYDRAZIDES USEFUL AS CELL PROLIFERATION AND ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2002-03-21 | — | — | WO | disclosed |
| US-6323228-B1 | INHIBITING ANGIOGENESIS IN A MAMMAL IN RECOGNIZED NEED OF SUCH TREATMENT COMPRISING ADMINISTERING TO THE MAMMAL WITH INDOLE SUBSTITUTED WITH HYDRAZIDES | ABBOTT LABORATORIES | 2001-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091148-A1 | 3-substituted indole antiproliferative angiogenesis inhibitors | MKI67, FLT4, IDO1 | MAPT 4828/4885ALDH1A1 98/4885LMNA 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.