Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.72 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.72 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.72 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.60 |
| ▸ | RAF1 | P04049 | 4/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7560881 | 1.00 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7670444 | 0.90 | MAPK14 (0.88) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7670440 | 0.90 | MAPK14 (0.88) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7699660 | 0.88 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7699663 | 0.88 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7678065 | 0.86 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL13819579 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL17938001 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6171143 | 0.83 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6171137 | 0.83 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131314-A4 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2002-05-02 | — | — | EP | disclosed |
| EP-1131314-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031065-A1 | COMPOUNDS HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 2000-06-02 | — | — | WO | disclosed |