Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 16/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.60 |
| ▸ | RAF1 | P04049 | 4/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699663 | 1.00 | MAPK14 (0.63) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7560881 | 0.88 | MAPK14 (0.72) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7560872 | 0.88 | MAPK14 (0.72) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7672894 | 0.81 | MAPK14 (0.62) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL15946565 | 0.78 | MAPK14 (0.85) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL17938001 | 0.77 | MAPK14 (1.00) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL13819579 | 0.77 | MAPK14 (1.00) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7670440 | 0.77 | MAPK14 (0.88) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7670444 | 0.77 | MAPK14 (0.88) | MAPK14MAPK11MAPK13MAPK12MAPK9 | |
| SCHEMBL7560906 | 0.77 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350744-B1 | PYRMIDINE OR PYRIDINE DERIVATIVES; ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS; CACHEXIA TREATMENT; INTERLEUKIN AND TUMOR NECROSIS FACTOR INHIBITORS | MERCK & CO., INC. | 2002-02-26 | — | — | US | disclosed |