Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.71 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.71 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.70 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.70 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.70 |
| ▸ | RAF1 | P04049 | 5/20 | 0.63 |
| ▸ | BRAF | P15056 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171119 | 0.93 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6170595 | 0.83 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6173136 | 0.83 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4936886 | 0.82 | CSNK1A1 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6170832 | 0.82 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6170994 | 0.81 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6174484 | 0.80 | CSNK1A1 (0.82) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6183122 | 0.79 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6172583 | 0.79 | CSNK1A1 (0.79) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6173735 | 0.78 | MAPK14 (0.81) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906307-A4 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0906307-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997047618-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 1997-12-18 | — | — | WO | disclosed |