Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 17/20 | 0.60 |
| ▸ | RXRB | P28702 | 15/20 | 0.60 |
| ▸ | RXRG | P48443 | 15/20 | 0.60 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.44 |
| ▸ | RARA | P10276 | 2/20 | 0.41 |
| ▸ | RARB | P10826 | 2/20 | 0.41 |
| ▸ | RARG | P13631 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570006 | 0.88 | RXRA (0.60) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7564506 | 0.88 | RXRA (0.46) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7569163 | 0.85 | RXRA (0.57) | RXRARXRBRXRGALOX5PTGS1 | |
| SCHEMBL8120734 | 0.85 | RXRA (0.57) | RXRARXRBRXRGRARARARB | |
| SCHEMBL8121956 | 0.84 | RXRA (0.54) | RXRARXRBRXRGSSTR5RARA | |
| SCHEMBL8110045 | 0.81 | RXRA (0.43) | RXRARXRBRXRGSSTR5RARA | |
| SCHEMBL8117493 | 0.78 | RXRA (0.56) | RXRARXRBRXRGALOX5PTGS1 | |
| SCHEMBL8123033 | 0.78 | RXRA (0.56) | RXRARXRBRXRGSSTR5RARA | |
| SCHEMBL8117130 | 0.78 | RXRA (0.45) | RXRARXRBRXRGRARARARB | |
| SCHEMBL20411352 | 0.78 | RXRA (0.72) | RXRARXRBRXRGRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228055-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012618-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6093838-A | FOR TREATING SKIN-RELATED DISEASES, INCLUDING ACTINIC KERATOSES, ARSENIC KERATOSES, ECZEMA | ALLERGAN SALES, INC. (US) | 2000-07-25 | — | — | US | disclosed |