Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.42 |
| ▸ | PHF8 | Q9UPP1 | 7/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KDM5C | P41229 | 4/20 | 0.41 |
| ▸ | KDM6B | O15054 | 2/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 7/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936921 | 0.71 | — | — | |
| SCHEMBL6721798 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL10640359 | 0.69 | LMNA (0.52) | LMNASLC15A2PHF8KDM2AEGLN1 | |
| Hydrochloric Acid SCHEMBL10640365 | 0.69 | LMNA (0.52) | LMNASLC15A2PHF8KDM2AEGLN1 | |
| Succinic Acid SCHEMBL5498204 | 0.68 | LMNA (0.58) | LMNASLC15A2PHF8KDM2AEGLN1 | |
| SCHEMBL11849463 | 0.67 | KDM4E (0.58) | LMNASLC15A2PHF8KDM2AEGLN1 | |
| SCHEMBL5079179 | 0.67 | — | — | |
| SCHEMBL11240416 | 0.67 | — | — | |
| SCHEMBL11240436 | 0.67 | — | — | |
| SCHEMBL11849467 | 0.67 | KDM4E (0.58) | LMNASLC15A2PHF8KDM2AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194443-A1 | CYSTEINYL PROTEASE INHIBITORS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| WO-2000078794-A1 | CYSTEINYL PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |