Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7564392 | 0.82 | MAPT (0.43) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7568401 | 0.79 | PDK1 (0.46) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7644896 | 0.79 | PDK1 (0.46) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3833229 | 0.73 | PDK1 (0.46) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7567499 | 0.73 | PDK1 (0.46) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL25888267 | 0.73 | PDK1 (0.49) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL16361796 | 0.73 | PDCD1 (0.50) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL16324249 | 0.73 | PDCD1 (0.50) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL16324250 | 0.73 | PDCD1 (0.50) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2905312 | 0.73 | MAPT (0.53) | MAPTKMT2ASMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222172-A1 | SYNTHESIS OF 1,3,5-TRISUBSTITUTED PYRAZOLES AND INTERMEDIATES THEREFORE | Bristol-Myers Squibb Pharma Company (US) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001029006-A1 | SYNTHESIS OF 1,3,5-TRISUBSTITUTED PYRAZOLES AND INTERMEDIATES THEREFORE | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-04-26 | — | — | WO | disclosed |