Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.44 |
| ▸ | PDE4A | P27815 | 7/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TIPARP | Q7Z3E1 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | NPY2R | P49146 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584184 | 0.92 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL6585673 | 0.77 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL7508465 | 0.74 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL6584281 | 0.72 | PDE4D (0.52) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL1415538 | 0.69 | IDO1 (0.48) | ALDH1A1 | |
| SCHEMBL6585114 | 0.68 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL6589108 | 0.67 | ALDH1A1 (0.45) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL6584375 | 0.67 | ALDH1A1 (0.45) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL6586794 | 0.64 | ALDH1A1 (0.48) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL6586037 | 0.63 | PDE4D (0.53) | PDE4BPDE4APDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042300-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032456-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |