Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433776 | 0.97 | NQO1 (0.34) | NQO1TSHRICMTMAPTLMNA | |
| SCHEMBL7446198 | 0.95 | NQO1 (0.38) | NQO1TSHRSMN1; SMN2ICMTMAPT | |
| SCHEMBL9280111 | 0.93 | TDP1 (0.35) | NQO1TSHRMAPTLMNAPOLB | |
| SCHEMBL7443698 | 0.90 | ESR1 (0.35) | NQO1ICMTMAPTLMNAALDH1A1 | |
| SCHEMBL7444618 | 0.89 | NQO1 (0.34) | NQO1ICMTMAPTLMNAALDH1A1 | |
| SCHEMBL7437376 | 0.89 | NQO1 (0.34) | NQO1ICMTMAPTLMNAALDH1A1 | |
| SCHEMBL7430123 | 0.89 | NQO1 (0.33) | NQO1HTTICMTKMT2A | |
| SCHEMBL7443469 | 0.89 | NQO1 (0.34) | NQO1HTTSMN1; SMN2ICMTMAPT | |
| SCHEMBL7444883 | 0.88 | NQO1 (0.33) | NQO1TSHRICMTLMNATP53 | |
| SCHEMBL7439820 | 0.87 | L3MBTL1 (0.37) | NQO1TSHRSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |