Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31260199 | 0.90 | CA2 (0.61) | CA2PARP10KMT2A | |
| SCHEMBL328637 | 0.88 | CA2 (0.64) | CA2KMT2A | |
| Hydrochloric Acid SCHEMBL5795470 | 0.86 | CA2 (0.61) | CA2KMT2A | |
| Bicarbonate SCHEMBL29794541 | 0.84 | CA2 (0.59) | CA2KMT2A | |
| SCHEMBL2734987 | 0.83 | SRD5A2 (0.62) | LTA4HEPHX2CA2PARP10 | |
| SCHEMBL3500048 | 0.83 | SRD5A2 (0.62) | LTA4HEPHX2CA2KMT2A | |
| SCHEMBL5858885 | 0.83 | CA2 (0.77) | CA2PARP10KMT2A | |
| SCHEMBL2848927 | 0.83 | MAOB (0.53) | MAOBPARP10 | |
| SCHEMBL13106182 | 0.82 | CA2 (0.57) | CA2MAOBKMT2A | |
| SCHEMBL2170992 | 0.82 | FFAR1 (0.53) | LTA4HEPHX2MAOBPARP10SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946495-B1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6353128-B1 | FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK. | ELI LILLY AND COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-0946495-A4 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0946495-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024756-A1 | PHENYL ACETAMIDES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |