SCHEMBL7564246

SCHEMBL7564246

CC(=O)Nc1ccc(O)c(Sc2csc(C(=O)N[C@@H]3C4CCN(CC4)[C@H]3C)c2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.38
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
HTT P42858 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
SLC18A3 Q16572 1/20 0.33
ALDH1A1 P00352 1/20 0.33
ABL1 P00519 1/20 0.33
RIN1 Q13671 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
MAPT P10636 2/20 0.32
LMNA P02545 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
NPC1 O15118 1/20 0.32
MAPK1 P28482 1/20 0.32
TSHR P16473 1/20 0.31
CYP3A4 P08684 1/20 0.31
KMT2A Q03164 1/20 0.31
SLC6A9 P48067 1/20 0.31
SMYD3 Q9H7B4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7703033 0.86 CHRNA7 (0.40) CHRNA7CHRNB2CHRNA4ALDH1A1MAPT
SCHEMBL7060372 0.85 HTT (0.40) CHRNA7CHRNB2CHRNA4HTTSMN1; SMN2
SCHEMBL7063886 0.81 CHRNB2 (0.39) CHRNA7CHRNB2CHRNA4HTTSMN1; SMN2
SCHEMBL7061872 0.76 CHRNA7 (0.39) CHRNA7CHRNB2CHRNA4SLC18A3L3MBTL1
SCHEMBL6882524 0.75 CHRNA7 (0.47) CHRNA7SLC18A3ALDH1A1L3MBTL1NPC1
SCHEMBL7064150 0.73 CHRNA7 (0.40) CHRNA7CHRNB2CHRNA4ALDH1A1MAPT
SCHEMBL7060514 0.73 CHRNA7 (0.49) CHRNA7CHRNB2CHRNA4SMN1; SMN2LMNA
SCHEMBL7130713 0.72 PTPN11 (0.44) CHRNA7CHRNB2CHRNA4SLC18A3SMYD3
SCHEMBL6879586 0.72 CHRNA7 (0.41) CHRNA7CHRNB2CHRNA4ALDH1A1L3MBTL1
SCHEMBL7064097 0.71 CHRNB2 (0.61) CHRNA7CHRNB2CHRNA4HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002017358-A2 QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS) PHARMACIA & UPJOHN COMPANY (US) 2002-02-28 WO disclosed