Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 6/20 | 0.64 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL755328 | 0.84 | NR3C2 (0.65) | NR3C2METSCN9ABRD4 | |
| SCHEMBL758490 | 0.81 | NR3C2 (0.58) | NR3C2ADRA1DADRA1ASCN9ABRD4 | |
| SCHEMBL756151 | 0.81 | NR3C2 (0.66) | NR3C2SCN9ABRD4 | |
| SCHEMBL756637 | 0.80 | NR3C2 (0.78) | NR3C2SCN9ABRD4 | |
| SCHEMBL754177 | 0.80 | NR3C2 (0.74) | NR3C2BRD4 | |
| SCHEMBL753700 | 0.79 | NR3C2 (0.69) | NR3C2ADRA1ASCN9ABRD4 | |
| SCHEMBL755857 | 0.79 | NR3C2 (0.80) | NR3C2ADRA1ASCN9ABRD4 | |
| Mt-3995 SCHEMBL753911 | 0.78 | NR3C2 (1.00) | NR3C2BRD4 | |
| SCHEMBL756145 | 0.78 | NR3C2 (0.72) | NR3C2SCN9ABRD4 | |
| SCHEMBL753806 | 0.78 | NR3C2 (0.79) | NR3C2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | claimed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | claimed |