Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 7/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753401 | 0.80 | NR3C2 (0.66) | NR3C2PDE4BPTGS2CACNA1BAPBA1 | |
| SCHEMBL753709 | 0.79 | NR3C2 (1.00) | NR3C2PTGS2CACNA1BAPBA1NR3C1 | |
| SCHEMBL755348 | 0.68 | NR3C2 (0.80) | NR3C2PTGS2CACNA1BAPBA1NR3C1 | |
| SCHEMBL756833 | 0.67 | NR3C2 (0.77) | NR3C2PGR | |
| SCHEMBL755200 | 0.66 | NR3C2 (0.75) | NR3C2PTGS2CACNA1BAPBA1NR3C1 | |
| SCHEMBL755391 | 0.65 | NR3C2 (0.72) | NR3C2PTGS2CACNA1BAPBA1PGR | |
| SCHEMBL754339 | 0.65 | NR3C2 (1.00) | NR3C2NR3C1PGRAR | |
| SCHEMBL755900 | 0.65 | NR3C2 (0.71) | NR3C2PTGS2CACNA1BAPBA1PGR | |
| SCHEMBL756074 | 0.64 | NR3C2 (0.70) | NR3C2PTGS2CACNA1BAPBA1PGR | |
| SCHEMBL757508 | 0.64 | NR3C2 (0.70) | NR3C2PTGS2CACNA1BAPBA1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | disclosed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | disclosed |