Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 6/20 | 0.77 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | BRD1 | O95696 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753709 | 0.87 | NR3C2 (1.00) | NR3C2MEN1KMT2ASCN9APGR | |
| SCHEMBL753196 | 0.80 | NR3C2 (0.77) | NR3C2KAT2BBRD1BRPF1MEN1 | |
| SCHEMBL755348 | 0.76 | NR3C2 (0.80) | NR3C2PGR | |
| SCHEMBL755200 | 0.74 | NR3C2 (0.75) | NR3C2PGR | |
| SCHEMBL754339 | 0.72 | NR3C2 (1.00) | NR3C2PGR | |
| SCHEMBL755904 | 0.72 | NR3C2 (0.77) | NR3C2KAT2BPKMADRA2CADRA1A | |
| SCHEMBL755857 | 0.71 | NR3C2 (0.80) | NR3C2MEN1KMT2AADRA2CADRA1A | |
| SCHEMBL756244 | 0.71 | NR3C2 (0.53) | NR3C2MEN1KMT2AADRA2CADRA1A | |
| SCHEMBL13164587 | 0.71 | ADRA2C (0.54) | KAT2BBRD1BRPF1MEN1PKM | |
| SCHEMBL754931 | 0.70 | NR3C2 (0.86) | NR3C2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-B9 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | disclosed |
| EP-1984345-B1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-08-31 | — | — | EP | disclosed |