Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | PTPRC | P08575 | 3/20 | 0.46 |
| ▸ | S100A4 | P26447 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773020 | 0.76 | ALDH1A1 (0.43) | TSHRALDH1A1TDP1PTPRCS100A4 | |
| SCHEMBL448167 | 0.73 | TSHR (0.47) | TSHRALDH1A1TDP1PTPRCS100A4 | |
| SCHEMBL7998504 | 0.73 | TDP1 (0.47) | TSHRALDH1A1TDP1PTPRCS100A4 | |
| SCHEMBL12282222 | 0.72 | PTPRC (0.53) | TSHRALDH1A1TDP1PTPRCS100A4 | |
| SCHEMBL1922728 | 0.72 | TSHR (0.46) | TSHRALDH1A1TDP1CYP3A4LMNA | |
| SCHEMBL1950848 | 0.72 | TSHR (0.46) | TSHRALDH1A1TDP1PTPRCS100A4 | |
| SCHEMBL18529408 | 0.72 | TSHR (0.46) | TSHRALDH1A1TDP1PTPRCS100A4 | |
| SCHEMBL10782657 | 0.72 | TDP1 (0.46) | TSHRALDH1A1TDP1PTPRCS100A4 | |
| SCHEMBL26624028 | 0.72 | ALDH1A1 (0.53) | TSHRALDH1A1TDP1PTPRCS100A4 | |
| SCHEMBL31448378 | 0.72 | ALDH1A1 (0.53) | TSHRALDH1A1TDP1PTPRCS100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228055-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012618-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6093838-A | FOR TREATING SKIN-RELATED DISEASES, INCLUDING ACTINIC KERATOSES, ARSENIC KERATOSES, ECZEMA | ALLERGAN SALES, INC. (US) | 2000-07-25 | — | — | US | disclosed |