Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.47 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.46 |
| ▸ | PSEN1 known ✓ | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 known ✓ | P49810 | 2/20 | 0.38 |
| ▸ | APH1B known ✓ | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN known ✓ | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A known ✓ | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN known ✓ | Q9NZ42 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 4/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22031145 | 0.98 | SLC6A2 (0.48) | SLC6A2BCHEACHEPDE4DPDPK1 | |
| SCHEMBL7565013 | 0.98 | SLC6A2 (0.48) | SLC6A2BCHEACHEPDE4DPDPK1 | |
| SCHEMBL22030353 | 0.98 | SLC6A2 (0.48) | SLC6A2BCHEACHEPDE4DPDPK1 | |
| SCHEMBL5804981 | 0.98 | SLC6A2 (0.48) | SLC6A2BCHEACHEPDE4DPDPK1 | |
| SCHEMBL23867773 | 0.88 | SLC6A2 (0.50) | SLC6A2BCHEACHEPDE4DPDPK1 | |
| SCHEMBL22239278 | 0.88 | SLC6A2 (0.50) | SLC6A2BCHEACHEPDE4DPDPK1 | |
| SCHEMBL19430369 | 0.88 | SLC6A2 (0.50) | SLC6A2BCHEACHEPDE4DPDPK1 | |
| SCHEMBL25909883 | 0.85 | SLC6A2 (0.46) | SLC6A2BCHEACHEPDE4DPDPK1 | |
| SCHEMBL19304068 | 0.83 | BCHE (0.45) | SLC6A2BCHEACHEPDE4DPDPK1 | |
| SCHEMBL8381817 | 0.82 | PDPK1 (0.42) | SLC6A2BCHEACHEPDE4DPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0830365-B1 | MODIFIED KOJIBIOSIDES ANALOGUES | ALBERTA RES COUNCIL (CA) | 2002-09-04 | — | — | EP | disclosed |
| US-5877157-A | Modified kojibioside analogues | ALBERTA RESEARCH COUNCIL (CA) | 1999-03-02 | — | — | US | disclosed |
| EP-0830365-A1 | MODIFIED KOJIBIOSIDES ANALOGUES | ALBERTA RESEARCH COUNCIL (CA) | 1998-03-25 | — | — | EP | disclosed |
| US-5633233-A | Modified kojibiosides analogues | ALBERTA RESEARCH COUNCIL (CA) | 1997-05-27 | — | — | US | disclosed |
| WO-1996040702-A1 | MODIFIED KOJIBIOSIDES ANALOGUES | ALBERTA RESEARCH COUNCIL (CA) | 1996-12-19 | — | — | WO | disclosed |