Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.70 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.70 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565453 | 0.90 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11GRM1 | |
| SCHEMBL7570546 | 0.86 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11GRM1 | |
| SCHEMBL7080451 | 0.83 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11GPR27 | |
| SCHEMBL7571487 | 0.83 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11GPR27 | |
| SCHEMBL1904637 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11TP53 | |
| SCHEMBL7079600 | 0.80 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27494244 | 0.79 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11GPR27 | |
| SCHEMBL27509293 | 0.79 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11TTR | |
| SCHEMBL7571478 | 0.79 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11GPR27 | |
| SCHEMBL7567075 | 0.77 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11GPR27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002083622-A2 | NOVEL AMINOPHENYL KETONE DERIVATIVES | LEO PHARMA A/S (DK) | 2002-10-24 | — | — | WO | claimed |
| WO-2002083622-A2 | NOVEL AMINOPHENYL KETONE DERIVATIVES | LEO PHARMA A/S (DK) | 2002-10-24 | — | — | WO | disclosed |