Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 18/20 | 1.00 |
| ▸ | TNKS2 | Q9H2K2 | 18/20 | 1.00 |
| ▸ | PARP1 | P09874 | 11/20 | 1.00 |
| ▸ | PARP2 | Q9UGN5 | 7/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | GUSB | P08236 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568249 | 0.86 | TNKS (1.00) | TNKSTNKS2PARP1PARP2NPC1 | |
| SCHEMBL15775325 | 0.86 | TNKS (1.00) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775476 | 0.84 | TNKS (1.00) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775692 | 0.83 | TNKS (1.00) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL7569320 | 0.83 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775949 | 0.83 | TNKS (1.00) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775251 | 0.83 | TNKS (1.00) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775474 | 0.83 | TNKS (1.00) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL17829611 | 0.81 | TNKS (0.72) | TNKSTNKS2PARP1PARP2NPC1 | |
| SCHEMBL6056819 | 0.80 | MGAM (0.68) | TNKSTNKS2PARP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| EP-0966476-B1 | Quinazolinone compounds | UNIV NEWCASTLE VENTURES LTD (GB) | 2002-09-04 | — | — | EP | disclosed |